“…you can forget Jack, Kate, Sawyer, Locke, and the dozen other characters that we’ve come to know intimately well over the past two years. When Lost is all said and done, it will stand exposed as the story of Desmond and Penelope, two people we barely know, and the lengths these crazy kids will go to in order to be together again — and the lengths to which Daddy Big Bucks will go to keep them apart.

In my view, Desmond/Penelope has suddenly become the defining narrative thread of Lost. Everything else is a subplot within that larger context. “

Wikipedia says this about Hume:
Historians most famously see Humean philosophy as a thoroughgoing form of skepticism, but many commentators have argued that the element of naturalism has no less importance in Hume’s philosophy. Hume scholarship has tended to oscillate over time between those who emphasize the skeptical side of Hume (such as the logical positivists), and those who emphasize the naturalist side (such as Don Garrett, Norman Kemp Smith, Kerri Skinner, Barry Stroud, and Galen Strawson).

Hume was heavily influenced by empiricists John Locke and George Berkeley, along with various Francophone writers such as Pierre Bayle, and various figures on the Anglophone intellectual landscape such as Isaac Newton, Samuel Clarke, Francis Hutcheson, and Joseph Butler.